李太生,男,1963年出生。畢業于北京協和醫學院,現任北京協和醫院感染內科主任,北京協和醫院艾滋病診療中心主任,清華大學醫學院特聘教授。中華醫學會感染病學分會候任主任委員兼艾滋病學組組長,中國醫學科學院艾滋病中心副主任。擅長感染性疾病的診治。2020年11月榮獲2020年全國先進工作者榮譽稱號。
人物經歷
教育經歷
1979年09月-1984年08月,在廣州中山醫學院醫療系本科畢業,獲醫學學士學位。
1987年09月-1990年02月,在北京協和醫科大學內科學學系研究生畢業,獲醫學碩士學位。
1995年12月-1999年01月,在法國高等應用研究院地球與生命科學系,獲免疫學博士學位。
工作經歷
1984年09月-1990年12月,北京協和醫院內科住院醫師,總住院醫師。
1990年12月-1993年10月,北京協和醫院內科感染內科主治醫師。
1993年10月-1995年12月,國家教育部公派赴巴黎Pitie-Salpetriere醫院感染與熱帶病學科進修學習。
1999年01月-1999年10月,北京協和醫院感染內科主治醫師。
1999年10月-2004年08月,北京協和醫院感染內科副主任醫師。
2002年07月-2010年11月,北京協和醫院內科學系副主任,感染內科副主任。
2002年07月-2017年12月,北京協和醫院內科學系總支書記。
2002年08月-至今,北京協和醫院艾滋病診療中心主任。
2004年09月-至今,北京協和醫院感染內科主任醫師。
2005年04月-至今,北京協和醫學院-清華大學醫學部博士生導師。
2010年11月-至今,北京協和醫院感染內科主任。
2018年04月-2021年03月,清華大學醫學院特聘教授。
擅長領域
李太生教授擅長的領域包括:
1. 發熱待查;
2. 各種感染性疾病的診治;
3. 免疫抑制人群的診治。
社會任職
李太生教授在社會任職方面也有豐富的經驗,曾任衛生部艾滋病臨床專家組副組長和衛生部艾滋病專家咨詢委員會臨床組副組長,中華醫學會傳染病與寄生蟲分會常委兼艾滋病學組組長、中華醫學會熱帶病和寄生蟲分會常委。他還曾任中華醫學會熱帶病和寄生蟲分會主委、感染病學分會副主委。
另外還是《Emerging Microbes & Infections》《Journal of Clinical Virology》《International Journal of Medical Informatics》《AIDS Care》《Journal of Medical Virology》《Therapeutics and Clinical Risk Management》《AIDS Research and Human Retroviruses》《International Journal of STD & AIDS》《SAGE Open Medicine》《Global Journal of 麻醉學》《BMJ Case Reports》《中華內科雜志》《中華傳染病雜志》《Chinese Medical Sciences Journal》《Clinical Intensive Care and Medicine》等學術雜志審稿人;還是《艾滋病》中文版主編, 《中華內科雜志》和《中華傳染病雜志》副主編。
主要成就
科研成就
1990年在國內讀碩士學位期間建立了ELISA法測定血清G-CSF水平,該發現已獲國家專利經國家批準用于臨床發熱的診斷及鑒別診斷。
1993年-1999年在法國學習期間先后在《科學》《自然醫學》《柳葉刀》等雜志上發表數篇論著。于1997年首先提出了艾滋病病人的免疫功能重建的新理論。
1998年在國際上提出艾滋病抗病毒免疫重建理論,并將免疫重建理論與我國抗艾實踐相結合,牽頭搭建全國艾滋病治療研究網絡。開創并不斷優化國產抗病毒藥物方案,創建了適宜國情的艾滋病抗病毒及免疫重建模式。
1999年回國后在北京協和醫院創建了臨床細胞免疫實驗室,建立了中國正常人的T細胞免疫功能正常值。并對中國艾滋病病人的免疫改變和免疫功能重建進行了開創性研究?;貒詠?,在各會議培訓班做有關艾滋病的講學報告近百次,聽講學員上萬人,為國家培訓了一大批防治艾滋病的骨干力量。現負責著包括歐盟美國NIH的艾滋病CIPRA項目在內的多項國際國內科研課題。
首建臨床細胞免疫表型檢測平臺并應用于疑難危重感染病的診治。在2003年非典疫情期間,于國際上最早報道SARS急性期T細胞計數出現顯著降低,為早期識別和疫情防控提供了重要依據。在臨床實踐中提出的“早期、小量、短程”的激素治療方案,大幅降低了SARS患者的死亡率及并發癥。
北京協和醫院感染內科李太生教授團隊的研究結果表明,以中藥雷公藤總苷改構研制的國家I類新藥羥基雷公藤內酯醇,對于長期抗病毒治療后免疫重建不佳的艾滋病,可有效提升其CD4+T淋巴細胞計數水平。這一研究結果在線發表于《柳葉刀—區域健康(西太平洋)》,是針對艾滋病免疫重建不全難題的一大突破。?
主持制定中國首部《艾滋病診療指南》,并向全國發布。又在國內率先提出艾滋病綜合診治的理念并建立綜合診治體系,報道了HIV感染者多系統疾病的發病規律,為改善感染者的長期生存質量提供技術支持。
主要論文
共發表學術論文近200篇,其中在SCI收錄的雜志上發表論文共40篇,被他人引用2000多次,在《科學》《自然醫學》《柳葉刀》等國際權威科學雜志上發表了多篇學術論文。
(帶*為通訊作者)
1、Luo L,Wang N,Yue Y,Han Y,Lv W,Liu Z,Qiu Z,Lu H,Tang X,Zhang T,Zhao M,He Y,Shenghua H,Wang M,Li Y,Huang S,Li Y,Liu J,Tuofu Z,Routy JP, Li T*. The effects of antiretroviral therapy initiation 時間 on HIV reservoir size in Chinese chronically HIV infected patients:a prospective,multi-site cohort study[J]. BMC Infectious Diseases,2019,19(1).
2、Luo L,Wang H,Fan H,Xie J,Qiu Z,Li T*. The clinical characteristics and the features of immunophenotype of peripheral lymphocytes of adult onset chronic active Epstein-Barr 病毒 disease at a Tertiary Care Hospital in Beijing. MEDICINE,97(9)(2018):e9854.
3、Luo L,Han Y,Song X,Zhu T,Zeng Y,Li T*. CD16-expressing monocytes correlate with arterial stiffness in HIV-infected ART-naive men,HIV CLIN TRIALS,19(2)(2018):39-45.
4、Sang X,Chen Y,Chen W,Xie J,Meng G,Zhong J,Li T*,Lu A*. Celastrol specifically inhibits the activation of NLRP3inflammasome.Sci China Life Sci.61(3)(2018):355-357.
5、Lu W,Feng Y,Jing F,Han Y,Lyu N,Liu F,Li J,Song X,Xie J,Qiu Z,Zhu T,Routy B,Routy JP,Li T*,Zhu B*. Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients,Front Microbiol,9(2018):1451.
6、Guo F,Cheng X,Hsieh E,Du X,Fu Q,Peng W,Li Y,Song X,Routy JP,Li T*. Prospective 等離子體 依法韋侖 concentration assessment in Chinese HIV-infected adults enrolled in a large multicentre study,HIV MED,19(7)(2018):440-451.
7、Guo F,Hsieh E,Lv W,Han Y,Xie J,Li YL,Song XJ,Li TS*. Cardiovascular disease risk among Chinese antiretroviral-na?ve adults with advanced HIV disease. BMC Infect Dis,17(1)(2017):287.
8、Xie J,Hsieh E,Sun MQ,Wang HL,Lv W,Fan HW,Li TS*. Delays in HIV Diagnosis and Associated Factors among Patients Presenting with AdvancedDisease at A Tertiary Care Hospital in Beijing,China. PLOS ONE. 12(8)(2017):e0182335.
9、Du XL,Kou HJ,Fu Q,Li YL,Zhu Z,Li TS*. Steady-state pharmacokinetics of tenofovir disoproxil fumarate in human immunodeficiency 病毒-infected Chinese patients. Expert Rev Clin Pharmacol,10(7)(2017):783-788.
10、Li YJ,Xie J,Wang HL,Han Y,Wang ND,Thio CL,Li TS*.. Elevated pre-treatment IL-18 level is associated with HBeAg seroconversion in HIV-HBV coinfection. 小紅傘 Ther,22(6)(2017):523-527.
11、Yue YS,Wang ND,Han Y,Zhu T,Xie J,Qiu ZF,Song XJ,Li YL,Routy JP,Wang JH,Li TS*. A higher CD4/CD8 ratio correlates with an ultralow cell-associated HIV-1 脫氧核糖核酸 level in chronically infected patients on antiretroviral therapy: a case control study. BMC Infect Dis,17(1)(2017):771.
12、Wang N,Li Y,Han Y,Xie J,Li T*. HIV sequence diversity during the early phase of infection is associated with HIV 脫氧核糖核酸 reductions during antiretroviral therapy. J Med Virol. 89(6)(2017):982-988.
13、Zhang H,Wang HL*,Zhong DR,Liu Y,Li NN,Zhang W,Xiao Y,Li TS*. Fatal Pulmonary Kaposi Sarcoma in an HIV seronegative 艾滋病 patient. Clin Respir J. 11(6)(2017):1040-1044.
14、Wang ND,Li TS*. Factors Associated with the Size of HIV 脫氧核糖核酸 Reservoir[J]. Chinese Medical Journal,130(2)(2017):224-230.
15、Qin L,Xie J,Qiu ZF,Cao W,Jiao Y,Jean‐Pierre Routy,and Li TS*. Aging of immune system: Immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults . AGING-US,8(5)(2016):848-859.
16、Guo FP,Li YJ,Qiu ZF,Lv W,Han Y,Xie J,Li YL,Song XJ,Du SS,Mehraj V,Li TS*,Routy JP. Baseline Naive CD4+ T-cell Level Predicting Immune Reconstitution in Treated HIV-infected Late Presenters. Chin Med J (Engl). 129(22)(2016):2683-2690.
17、Xie J,Han Y,Qiu ZF,Li YJ,Li YL,Song XJ,Wang HL,Chloe L Thio,Li TS*. Prevalence of hepatitis B and C 病毒es in HIV-positive patients in China: a cross-sectional study. J Int 艾滋病 Soc,19:20659(2016).
18、Li YJ,Xie J,Han Y,Wang HL,Zhu T,Wang ND,Lv W,Guo FP,Qiu ZF,Li YL,DuSS,Song XJ,Chloe L Thio,Li TS*.Lamivudine monotherapy-based cART is efficacious for HBV treatment in HIV/HBV co-infection when baseline HBV 脫氧核糖核酸<20,000IU/ml. J Acquir Immune DeficSyndr. 72(1)(2016): 39-45.
19、Li YJ,Xie J,Han Y,汪姓 HL,Lv W,Guo FP,Qiu ZF,Li YL,Du SS,Song XJ,Zhu T,Thio,CL,Li TS*. Combination Antiretroviral Therapy Is Associated With Reduction in Liver Fibrosis Scores in HIV-1-Infected Subjects. MEDICINE,95(5)(2016):e2660.
20、Hsieh E,Fraenke L,Han Y,Xia W,Insogna KL,Yin MT,Zhu T,Cheng X,Li TS*. Longitudinal increase in vitamin D binding protein levels after initiation of 替諾福韋/lamivudine/依法韋侖 among individuals with HIV. AIDS. 30(12)(2016):1935-1942.
21、Li HP,Chang S,Han Y,Zhuang D,Li L,Liu Y,Liu S,Bao Z,Zhang W,Song H,Li TS*,Li J*. The prevalence of drug resistance among treatment-na?ve HI德國V-1導彈-infected individuals in China during pre- and post-2004[J]. BMC infectious diseases,16(605)(2016).
22、Han Y,Li YJ,Xie J,Qiu ZF,Li YL,Song XJ,Zhu T,Li TS*.Week 120 efficacy of 替諾福韋,lamivudine and lopinavir/r-based second-line antiretroviral therapy in treatment-experienced HIV patients. PLoS One.10(3)(2015)e120705.
23、Dou HT,Xu Y,Li TS*. Application of the DiversiLab system for tracing the source of the mixed infections caused by Cryptococcus neoformans var. grubii from a patient with systemic lupus erythematosus. Mycoses. 58(3)(2015):149-159.
24、Zhang CD,Chow FC,Han Y,Xie J,Qiu Z,Guo F,Li Y,汪姓 H,Li TS*. Multicenter cohort study of 糖尿病 mellitus and impaired fasting glucose in HIV-infected patients in China. J Acquir Immune DeficSyndr. 68(3)(2015):298-303.
25、GE Y& Li TS*.May early intervention with intravenous immunoglobulin pose a potentially successful treatment for Ebola virus infection? Life Sciences58(1)(2015):108-110.
26、Li YJ,Gu LJ,Han Y,Xie J,汪姓 HL,Lv W,Song XJ,Li YL,Iwamoto,A,Ishida T,Li TS*. HIV-1 Subtype B/B ' and Baseline Drug Resistance Mutation Are Associated With Virologic Failure: A Multicenter Cohort Study in China. J艾滋病-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,68(3)(2015):289-297.
27、Hsieh E,Fraenkel L,Xia W,Hu YY,Han Y,Insogna K,Yin MT,Xie J,Zhu T,Li TS*. Increased bone resorption during 替諾福韋 plus lopinavir/ritonavir therapy in Chinese individuals with HIV. Osteoporos Int.26(3)(2015):1035-1044.
28、Gu LJ,Han Y,Li Y,Zhu T,Song X,Huang Y,Yang F,Guan S,Xie J,Gohda J,Hosoya N,Kawana-Tachikawa A,Liu W,Gao GF,Iwamoto A,Li TS*,Ishida T. Emergence of Lamivudine-Resistant HBV during Antiretroviral Therapy Including Lamivudine for Patients Coinfected with HIV and HBV in China. PLoS One. 10(8)(2015) e0134539.
29、Li TS*,Xie J,Li Y,Routy JP,Li Y,Han Y,Qiu Z,Lv W,Song X,Sun M,Zhang X,汪姓 F,Jiang H. Tripterygium wilfordii Hook F extract in cART-treated HIV patients with poor immune response: a pilot study to assess its immunomodulatory effects and safety. HIV Clin Trials. 16(2)(2015):49-56.
30、Fan HW,Guo FP,Li YJ,Li N,Li TS*. Prevalence of thrombocytopenia among Chinese adult antiretroviral-na?veHIV-positive patients. Chin Med J (Engl). 128(4)(2015):459-464.
31、Li YJ,Han Y,Xie J,Gu L,Li W,汪姓 H,Lv W,Song X,Li Y,Routy JP,Ishida T,Iwamoto A,Li TS*; CACT0810 group. CRF01_AE subtype is associated with X4 tropism and fast HIV progression in Chinese patients infected through sexual transmission. 艾滋病.28(4)(2014):521-530.
32、Guo FP,Liu Y,Li Y,Fan H,Li TS*. Disseminated Mycobacterium avium complex infection manifested as Brown-Séquard 綜合征 in an HIV-infected patient. Chin Med J (Engl). 127(4)(2014):799.
33、Luo L,Zeng Y,Li TS*,Lv W,汪姓 HL,Guo FP,Han Y,Xie J,Qiu ZF,Li YL,Song XJ,Zhu T,Zhang XY,Li L,Ye YC,He Y,Lu HZ,Huang AQ,Tang XP,Wang H,Zhang T,Gao GJ,Lei JK,Wu XH,Sun YT,Bai JS,Li KL. . Prospective Echocardiographic Assessment of Cardiac Structure and Function in Chinese Persons Living With HIV. Clinical Infectious Diseases,58(10)(2014):1459-1466.
34、Li TS*,Guo F,Li Y,Zhang C,Han Y,Lye W,He Y,Lu H,Xie J,Huang A,Li Y,Tang X,Wang H,Zhang T,Gao G,Lei J,Zhang X,Wu X,Sun Y,Bai J,Luo L,Wang H. An antiretroviral regimen containing 6 months of 司他夫定 followed by long-term 齊多夫定 for first-line HIV therapy is optimal in resource-limited settings: a prospective,multicenter study in China. Chin Med J (Engl). 127(1)(2014):59-65.
35、Cao W,QiuZF,Zhu T,Li Y,Han Y,Li TS*.CD8+ T cell responses specific for hepatitis B 病毒 core protein in patients with chronic hepatitis B virus infection. Journal of Clinical Virology.61(2014): 40-46.
36、Hsieh E,Fraenkel L,Bradley EH,Xia W,Insogna KL,Cui Q,Li K,Li TS*.骨質疏松癥 knowledge,self-efficacy,and health beliefs among Chinese individuals with HIV. Arch Osteoporos. 9(1)(2014):201.
37、Ge Y,Li TS*,Liu ZY,Liu M,Guan H,Chen L,Tian Y,Zhuang Q. A rare cause of fever of unknown origin-cervical spinal cord lesion. Chin Med J (Engl).127(19)(2014):3517-3518.
38、Hsieh E,Fraenkel L,Bradley E,Xia W,Qu C,Ling L,Insogna K,Li TS*. 骨質疏松癥 knowledge,self-efficacy,and health beliefs among chinese men and women with HIV. Ann Rheum Dis. 73 Suppl 1(2014):A62-3.
39、Hsieh E,Fraenkel L,Xia W,Hu Y,Han Y,Insogna K,Yin MT,Xie J,Zhu T,Li TS*.Increased bone turnover after switch to 替諾福韋 + lopinavir/ritonavir in chinese HIV + patients. Ann Rheum Dis. 73 Suppl 1(2014):A62.
40、Kou HJ,Du X,Li Y,Xie J,Qiu Z,Ye M,Fu Q,Han Y,Zhu Z,Li TS*,Comparison of nevirapine 等離子體 concentrations between 鉛in and steady-state periods in Chinese HIV-infected patients. PLoS One. 8(1)(2013):e52950.
41、Cao Y,Gong M,Han Y,Xie J,Li X,Zhang L,Li Y,Song X,Zhu T,Li TS*. Prevalence and risk factors for chronic 腎臟 disease among HIV-infected antiretroviral therapy-na?ve patients in Chinese mainland:A multicenter cross-sectional study. Nephrology (Carlton). 18(4)(2013):307-312.
42、Zhang C,Wang W,Zhou M,Han H,Xie J,Qiu Z,Guo F,Li Y,Wang H,Ghanem KG,Li TS*. The Interaction of CD4 T-Cell 計數 and Nevirapine Hepatotoxicity in China: A Change in National Treatment Guidelines May Be Warranted. J Acquir Immune Defic Syndr.62(2013):540–545.
43、Cao Y,Han Y,Xie J,Cui Q,Zhang L,Li Y,Li Y,Song X,Zhu T,Li TS*. Impact of a 替諾福韋 disoproxil fumarate plus ritonavir-boosted Prorese inhibitor-based regimen on renal function in HIV-infected Individuals:a prospective,multicenter study. BMC Infect Dis.13(2013):301.
44、Zhang LX,Su Y,Hsieh E,Xia W,Xie J,Han Y,Cao Y,Li Y,Song X,Zhu T,Li TS*,Yu W. Bone turnover and bone mineral 密度 in HIV-1 infected Chinese taking highly active antiretroviral therapy-a prospective observational study. BMC MusculoskeletDisord. 14(2013):224.
45、Wang HL,Ghanem KG,Wang P,Yang S,Li TS*. Listeriosis at a tertiary care hospital in beijing,china: High prevalence of non-clustered healthcare-associated cases among adult patients. Clin Infect Dis.56(5)(2013):666-676.
46、Kou H,Du X,Li Y,Fu Q,Zhu Z,Li TS*.Quantification of tenofovir in human 等離子體 by 固體phase extraction and high-performance 羧基液體丁腈橡膠 chromatography coupled with UV detection. Ther Drug Monit. 34(5)(2012):593-598.
47、Wang H,Li Y,Zhang C,Han Y,Zhang X,Zhu T,Li TS*. Immunological and virological responses to cART in HIV/HBV co-infected patients from a multicenter cohort. AIDS. 26(14)(2012):1755-1763.
48、Kou HJ,Ye M,Fu Q,Han Y,Du X,Xie J,Zhu Z,Li TS*. Simultaneous quantification of lopinavir and ritonavir in human 等離子體 by high performance 羧基液體丁腈橡膠 chromatography coupled with UV detection. SciChina Life Sci. 55(4)(2012):321-327.
49、Li YJ,Wang HL,Li TS*. Hepatitis B virus/human immunodeficiency virus coinfection: Interaction among human immunodeficiency virus infection,chronic hepatitis B virus infection,and host immunity. Chin Med J (Engl). 125(13)(2012):2371-2377.
50、Li,CG; Yang,PH; Sun,Y; Li,TS; Wang,C; Wang,Z; Zou,Z; Yan,YW; Wang,W; Wang,C; Chen,ZW; Xing,L; Tang,C; Ju,XW; Guo,F; Deng,JJ; Zhao,Y; Yang,P; Tang,J; Wang,HL; Zhao,ZP; Yin,ZN; Cao,B; Wang,XL; Jiang,CY. 2012. IL-17 response mediates acute lung injury induced by the 2009 pandemic 流行性感冒 A (H1N1) 病毒. CELL RESEARCH,22(3):528-538.
51、Liu LF,Wang L,Fu Q,Zhu Z,Xie J,Han Y,Liu ZY,Ye M,Li TS*. Steady-state pharmacokinetics of 齊多夫定 in ChineseHIV-infected patients. Chin Med J (Engl). 125(11)(2012):1931-1935.
52、Li TS*,Wu N.CD31(+) Cell Percentage Correlation With Speed of CD4(+) T-Cell 計數 Recovery in HIV-Infected Adults Is Reversed in Children:Higher Thymic Output May Be Responsible Reply. CLIN INFECT DIS .55(2) (2012):307-309.
53、Cao W,Qiu ZF,Li TS*. Parallel decline of CD8+CD38+ lymphocytes and viremia in treated hepatitis B patients. World J Gastroenterol. 17(17)(2011):2191-2198.
54、Liu LF,Xie J,Sun J,Han Y,Zhang C,Fan H,Liu Z,Qiu Z,He Y,Li TS*. Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory 綜合征 正冠狀病毒亞科 components and neutralizing activities in recovered patients[J]. Scandinavian journal of infectious diseases,43(6-7)(2011):515-521.
55、Li TS*,Wu N,Dai Y,Qiu Z,Han Y,Xie J,Zhu T,Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy. Clin Infect Dis. 53(9)(2011):944-51.
56、Han Y,Wu N,Zhu WJ,Li YL,Zuo LY,Ye JJ,Qiu ZF,Xie J and Li TS*.Detection of HIV-1 viruses in tears of patients evenunder long-term HAART,艾滋病,25(15)(2011):1925-1927.
57、Wang J,Kou H,Fu Q,Han Y,Qiu Z,Zuo L,Li Y,Zhu Z,Ye M,Ma Q,Li TS*.Nevirapine 等離子體 concentrations are associated with virologic response and hepatotoxicity in Chinese patients with HIV infection. PLoS One. 6(10)(2011):e26739.
58、Luo L,Li TS*.Overviewof antiretroviral treatment in china:advancement and challenges Chinese Medical Journal;124(3)(2011):440-444.
59、Ye M,Wang L,Fu Q,Zhu Z,Li P,Li TS*. Steady-State Pharmacokinetics of Lamivudine Once-Daily Versus TWICEDaily Dosing in Chinese HIV-Infected Patients. HIV Clin Trials. 11(4)(2010):230-237.
60、Ye Y,Zeng Y,Li X,Zhang S,Fang Q,Luo L,Qiu Z,Han Y,Li TS*. Human immunodeficiency 病毒 Infection: An Independent Risk Factor of Peripheral Arterial Disease. J Acquir Immune DeficSyndr. 53(2)(2010):276-278.
61、Guo FP,Lv W,Han Y,Qiu ZF,Zuo LY,Li YL,Li TS*. Impact of Hepatitis C Virus Coinfection on HAART in HIV-Infected Individuals: Multicentric Observation Cohort. J艾滋病-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,54(2)(2010):137-142.
62、Luo L,Ye Y,Guo F,Zuo L,Li Y,Qiu Z,Han Y,Li L,Zeng Y*,Li TS*. Assessment of cardiac diastolic dys函數 in HIV-infected people without cardiovascular symptoms in China. Int J STD AIDS;21(12)(2010):814-818.
63、Zeng Y,Ye Yc,Luo L,Qiu ZF,Han Y,Li XM,Fang QA,Zang SY and Li TS*.Premature atherosclerosis in patients with acquired immunodeficiency 綜合征 Chinese Medical Journal,123(23)(2010):3396-3399.
64、Cao ZL,Liu LF,Du LY,Zhang C,Jiang S,Li TS*,He YX*. Potent and persistent antibody responses against the receptor-binding domain of 嚴重急性呼吸綜合征CoV spike protein in recovered patients[J]. Virology journal,7(2010):299.
65、Xie J,Jiao Y,Qiu Z,Li Q,Li TS*. Significant elevation of B cells at acute stage in enterovirus 71-infected children with central nervous system involvement. Scand J Infect Dis. 42(11-12)(2010):931-935.
66、Liu J,Wu P,Gao F,Qi JX,Kawana-Tachikawa,A,Xie J,Vavricka,CJ, Iwamoto,A,Li TS*,Gao GF. Novel Immunodominant 多肽 Presentation Strategy: a Featured HLA-A*2402-Restricted Cytotoxic T-Lymphocyte Epitope Stabilized by Intrachain 氫 Bonds from Severe Acute Respiratory 綜合征 正冠狀病毒亞科 Nucleocapsid Protein. JOURNAL OF VIROLOGY. 84(22)(2010):11849-11857.
67、Jiao Y,Qiu ZF,Xie J,Li DJ,Li TS*. Reference ranges and agerelated changes of peripheral blood lymphocyte subsets in Chinese healthy adults. Sci China C Life Sci,52(7)(2009):643-650.
68、Liu ZY,Guo FP,Han Y,Qiu ZF,Zuo LY,Li YL,Li TS*. Impact of baseline CD4(+) T cell counts on the efficacy of nevirapine-based highly active antiretroviral therapy in Chinese HIV/艾滋病 patients: a prospective,multicentric study. Chin Med J (Engl). 122(20)(2009):2497-2502.
69、Luo L,Zhang L,Tao MM,Qiu ZF,Xie J,Han Y,Li M,Li TS*. Adiponectin and Leptin Levels in Chinese Patients with HIV-Related Lipodystrophy: A 30-Month Prospective Study. 艾滋病 Res Hum Retroviruses. 25(12)(2009):1265-1272.
70、Zhang HW,Qiu ZF,Jiao Y,Wang AX,Li TS*. HIV-specific CD8(+) T cell responses to HXB2 Gag and Nef 多肽 pools in Chinese HIV/AIDS patients. SCIENCE IN CHINA SERIES C-LIFE SCIENCES. 52(9)(2009):841-846.
71、Luo L,Li TS*.Idiopathic CD4 Lymphocytopenia and opportunistic infection an update.FEMSImmunol Med Microbiol.54(2008):283-289.
72、Li TS*,Dai Y,Kuang JQ,Jiang JM,Han Y,Qiu ZF,Xie J,Zu,LY,Li YL. Three Generic Nevirapine-Based Antiretroviral Treatments in Chinese HIV/AIDS Patients: Multicentric Observation Cohort. PLOS ONE. 3(12)(2008):e3918.
73、Qing ML,Li TS*,Han Y,Qiu ZF,Jiao Y. Accelerating effect of human leukocyte 抗原Bw6 homozygosity on disease progression in Chinese HIV-1 - Infected patients. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 41(2)(2006):137-139.
74、Jiao Y, Xie J,Li TS*,Han Y,Qiu ZF,Zuo LY,Wang AX. Correlation between Gag-specific CD8 T-cell responses,viral load and CD4 計數 in HIV-1 infection is dependent on disease status. J Acquir Immune DeficSyndr,42(3)(2006):263-268.
75、Jiao Y,Li TS*,Xie J,Han Y,Qiu ZF,Zuo LY,Thomas Mourez,Wang AX. Association between Nef-Specific CD8+ T-Cell Responses and disease progression in HIV-1 Subtype B Infection. Chinese Medical Journal,119(19)(2006):1609-1615.
76、Wang AX,Wang FS,Wang QY,Jian W,Feng TJ,Lu HZ,Sun HQ,Sun YT,Ye HH,Li TS*,Li XW,Liu ZY,Xing YL,Yun H,Ning W,Hao W,Wu NP,Zhang FJ,Zhou ZQ,Gong EC,Zhao HX,Min Z,Tang XP,Xu LZ,Xu XY,Cao YZ,Kang LY,Yan J,Cai WP,Fan QB,Pan XZ. Guidelines for diagnosis and treatment of HIV/AIDS in China (2005). CHINESE MEDICAL JOURNAL. 119(19)(2006): 1589-1608.
77、Dai Y,QiuZF,Li TS*,Han Y,Zuo LY,Xie J,Ma XJ,Liu ZY,Wang AX. Clinical outcomes and immune reconstitution in 103 advanced AIDS patients undergoing 12-month highly active antiretroviral therapy. Chinese Medical Journal,119(20)(2006):1677-1682.
78、Li TS*,Xie J,He Y,Fan H,Baril L,Qiu Z,Han Y,Xu W,Zhang W,You H,Zuo Y,Fang Q,Yu J,Chen Z,Zhang L. Long-term persistence of robust antibody and cytotoxic T cell responses in recovered patients infected with 嚴重急性呼吸綜合征 正冠狀病毒亞科[J]. PloS one,1(2006):e241.
79、Li TS*,Qiu ZF,Zhang LQ,Han Y,He W,Liu ZY,Ma XJ,Fan HW,Lu W,Xie J,Wang HL,Deng GH,Wang A. Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory 綜合征 JOURNAL OF INFECTIOUS DISEASES. 189(4)(2004):648-651.
80、LI TS*,Qiu ZF,Han Y,Wang Z,Fan HW,Lu W,Xie J,Ma XJ and Wang AX. Rapid loss of both CD4~+ and CD8~+ T lymphocyte subsets during the acute phase of severe acute respiratory 綜合征[J]. Chinese medicaljournal,116(7)(2003):985-987.
81、Li TS; Tubiana R; Fillet AM; Autran B; Katlama,C. Negative result of 巨細胞病毒 blood culture with restoration of CD4(+) T-cell reactivity to cytomegalovirus after HAART in an HIV-1-infected patient.JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES.20(5)(1999):514-515.
82、Gorochov,G; Neumann,AU; Kereveur,A; Parizot,C; Li,TS; Katlama,C; Karmochkine,M; Raguin,G; Autran,B; Debre,P. 1998. Perturbation of CD4(+) and CD8(+) T-cell repertoires during progression to AIDS and regulation of the CD4(+) repertoire during antiviral therapy. NATURE MEDICINE. 4(2):215-221.
83、Li TS;Tubiana,R; Katlama,C; Calvez,V; AitMohand,H; Autran,B. Long-lasting recovery in CD4+ T cell function minors viral load reduction after highly active anti-retroviral therapy in patients with advanced HIV disease. Lancet. 351(1998):1682-1686.
84、Autran,B; Carcelain,G; Li,TS; Blanc,C; Mathez,D; Tubiana,R; Katlama,C; Debre,P; Leibowitch,J. 1997. Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease. SCIENCE.277(5322):112-116.
著作譯作
1. 李太生共同主編,《國家衛生和計劃生育住院醫師規范化教材內科學感染科分冊》,人民衛生出版社出版,2016年,北京。
2. 李太生主編,《中華醫學百科全書》感染性疾病學卷,中國協和醫科大學出版社,2013年,北京。
3. 李太生,艾滋病的免疫應答和免疫重建研究進展,第496-511頁,《中國艾滋病流行與控制》,王隴德主編,北京出版社,2006,北京。
4. 李太生,艾滋病,第175-191頁,肺孢子菌病,不明原因發熱的診斷思維,418-421頁,558-563頁,免疫缺陷病患者的感染,586-599頁,《感染病學》,李蘭娟等主編,人民衛生出版社,2005,北京。
獲得榮譽
法國優秀外國醫師獎(Vctoria Hugo獎)(1999年)
中華醫學會醫藥衛生科技進步二等獎(2002年)
北京市科技進步三等獎(2003年)
北京市首都《五一》勞動獎章獲得者(2003年)
全國抗擊嚴重急性呼吸綜合征優秀科技工作者(2003年)
全國留學回國人員先進個人代表(2003年)
全國五一勞動獎章(2004年)
第八屆全國青年科技獎獲得者(2004年)
國家級新世紀“百千萬人才工程”(2006年)
中華醫學會醫藥衛生科技進步三等獎(2007年)
國務院特殊津貼獲得者(2008年)
北京市科技進步二等獎(2009年)
中國醫學科學院“群眾心目中的優秀黨員”(2010年)
中國醫學科學院“協和學者特聘教授”(2010年)
華夏醫學科技獎一等獎(2011年)
中華預防醫學會科學技術二等獎(2011年)
北京市科學技術獎二等獎(2011年)
當選首批國家“萬人計劃”科技創新領軍人才(2014年)
中華醫學科技獎二等獎(2015年)
法國國家醫學科學院“塞維雅”獎(2016年)
吳階平醫藥創新獎(2018年)
入圍北京市2020年全國勞動模范和先進工作者推薦人選(2020年)
人物事件
2020年1月21日,新冠肺炎被正式列入乙類傳染病,按甲類傳染病預防。北京協和醫院感染內科主任李太生領銜30位專家擬定了《北京北京協和醫院關于“新型冠狀病毒感染的肺炎”診療建議方案》,前瞻性地提出可考慮應用免疫球蛋白以及康復期病人血漿治療的方法,為后期實際診療提供了參考方向。
疫情暴發之初,李太生就報名支援武漢,2月7日,李太生,帶領協和醫院第二批醫療隊飛抵武漢,與第一批醫療隊共同接管華中科技大學同濟醫學院附屬同濟醫院中法新城院區C9西病區ICU。
2020年4月15日,北京協和醫院援鄂醫療隊最后一批撤離,但李太生和5名同事卻留了下來,繼續救治重癥病人。
科普宣傳
李太生教授積極參與科普宣傳工作,曾在《養生堂》《職場健康課》《人民網》等進行科普宣傳。
參考資料 >
李太生.北京協和醫院.2024-03-29
李太生.北京協和醫院.2024-03-29
直播預告 | 央視《健康之路》訪談李太生主任:給艾滋病人有質量的生命.北京協和醫院.2022-02-17
李太生.北京協和醫院.2022-02-17
突破!北京協和醫院團隊以雷公藤改構新藥治療艾滋病.今日頭條-北京日報客戶端.2023-03-22
2018年吳階平醫學獎揭曉 兩位院士獲獎.人民網.2018-10-21
北京市2020年全國勞動模范和先進工作者推薦人選公示|全國勞動模范|先進工作者_新浪新聞.新浪新聞.2020-07-23
【你有多美】李太生:北京協和醫院援鄂醫療隊的“定海神針”.澎湃新聞.2024-03-29
留守救治 最后8名專家昨日撤離武漢.澎湃新聞.2020-04-28