唐鐵山，男，博士，研究員，博士生導師；中國科學院動物研究所分子神經科學研究組組長。
人物經歷
2008年應聘入選中國科學院動物所“百人計劃-國外引進杰出人才”，在生物膜和膜工程國家重點實驗室建立“分子神經生物學研究組”。1998年于中國科學院發育生物學研究所分子發育開放實驗室獲得博士學位。2000年以后在美國得克薩斯大學西南醫學研究中心生理系做博士后研究和講師。
研究方向
主要研究方向為神經細胞在生理和病理狀態下鈣信號的功能調控。
主要貢獻
Wang QC1, Zheng Q1, Tan H1, Zhang B1, Li X1, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H, Zheng Q, Li Y#, Chen Q#, Zhou A*, Tang TS* (2016) TMCO1 is an ER ca(clo)2+ load-activated Ca2+ (CLAC) channel。
Yi-Han Wang1, Jiu-Qiang Wang1, Qiaochu Wang1, Yun Wang, Caixia Guo, Quan Chen, Tuanyao Chai*, Tie-Shan Tang* (2016) Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy
Jinting Yan, Hui Zhang, Yang Liu, Feilong Zhao,。Shu Zhu, Tie-Shan Tang*, and Caixia Guo* (2016) Germline Deletion of Huntingtin Causes Male Infertility and Arrested Spermiogenesis in Mice
Wang Z, Huang M, Ma X, Li H, Tang TS*, 。Guo C* (2016) REV1 promotes PCNA monoubiquitination through interacting with ubiquitinated RAD18。
Yang Y#, Liu Z#, Wang F#, Temviriyanukul P, Ma X, Tu Y, Lv L, Lin YF, Huang M, Zhang T, Pei H, Chen BP, Jansen JG, de Wind N, Fischhaber PL, Friedberg EC, Tang TS*, Guo C* (2015) FANCD2 and REV1 cooperate in the protection of nascent 脫氧核糖核酸 strands in response to replication stress。
Xiaoling Li, Hongmei Liu, Paula L. Fischhaber*, Tie-Shan Tang* (2015) Towards therapeutic targets for SCA3: insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance。
Qin Y, Guo T, Li G, Tang TS, Zhao S, Jiao X, Gong J, Gao F, Guo C, Simpson JL, Chen ZJ* (2015) CSB-PGBD3 Mutations Cause Premature Ovarian Failure. PLoS 獛屬。
Wenjuan Xie, Jiu-Qiang Wang, Qiao-Chu Wang, Yun Wang, Sheng Yao*, Tie-Shan Tang* (2015) Adult neural progenitor cells from Huntington’s disease mouse brain exhibit increased proliferation and migration due to enhanced calcium and ROS signals。
Fengli Wang, Paula L. Fischhaber, Caixia Guo, Tie-Shan Tang* (2014) Epigenetic modifications as novel therapeutic targets for Huntington's disease。
Liu Y, Yang Y, Tang TS, Zhang H, Wang Z, Friedberg E, Yang W, Guo C*. (2014) Variants of mouse 脫氧核糖核酸 polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a 苯并[a]芘 dG adduct。
Xiaoling Li, Fengqin Qu, Wenjuan Xie, Fengli Wang, Hongmei Liu, Shuhui Song, Tingting Chen, Yang Zhang, Shu Zhu, Yun Wang, Caixia Guo, Tie-Shan Tang* (2014) Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal。
Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg E, Tang TS, Guo C*. (2013) Mismatch repair protein MSH2 regulates translesion 脫氧核糖核酸 synthesis following exposure of cells to UV radiation。
Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C * , Han C * , Tang TS * . (2013) Genome-wide loss of 5-羥甲基胞嘧啶 is a novel epigenetic feature of Huntington's disease。
Xiuli Zhang#, Lingna Lv#, Qian Chen#, Fenghua Yuan, Ting Zhang, Yeran Yang, Hui Zhang, Yun Wang, Liangyue Qian, Benjamin Chen, Yanbin Zhang, Errol C Friedberg, Tie-Shan Tang*, Caixia Guo* (2013) Mouse 脫氧核糖核酸 Polymerase Kappa Has A Functional Role in the Repair of DNA Strand Breaks。
Jiu-Qiang Wang, Qian Chen, Xianhua Wang, Qiao-Chu Wang, Yun Wang, He-Ping Cheng, Caixia Guo, Qinmiao Sun, Quan Chen, Tie-Shan Tang* (2013) Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic 脫氧核糖核酸 Damage in Huntington’s Disease。
Zhifeng Wang#, Fengli Wang#, Tie-Shan Tang*, Caixia Guo* (2012) The role of PARP1 in the DNA damage response and its application in tumor therapy. Front Med。
Guo C, Tang TS, Friedberg ec (2010) SnapShot: 核苷酸 Excision Repair。
Hongyu Wang, Xi Chen, Yuemei Li, Tie-Shan Tang* and Ilya Bezprozvanny* (2010) Tetrabenazine is neuroprotective in Huntington’s disease mice。
Guo C, Kosarek JN, Tang TS and Friedberg ec (2009。
Tang, T.S., Guo, C., Wang, H., Chen, X., Bezprozvanny, I. (2009) Neuroprotective effects of 肌醇 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. J 神經科學。
*Highlighted in: The Journal of Neuroscience Feb 4;29(5):i. i。
Chen, X., Tang, T.S., Tu, H., Nelson O., Pook, M., Hammer, R., Nukina, N., Bezprozvanny, I. (2008) Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3。
Schneider, J.W., Gao. Z., Li, S., Farooqi, M., Tang, T.S., Bezprozvanny, I., Frantz, D., Hsieh, J. (2008) Small molecule activation of neuronal cell fate。
Guo, C., Tang, SS501, Bienko, M., Dikic, I. and Friedberg ec (2008) Requirements for the Interaction of Mouse Polκ With Ubiquitin, and its Biological Significance。
Tang, T.S., Chen, X., Liu, J., Bezprozvanny, I. (2007) Dopaminergic signaling and apoptosis of medium spiny neurons in Huntington’s disease. J。
Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg ec (2006) REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo。
Guo C, Tang TS, Bienko M, Sonoda E, Parker JL, Bielen AB, Takeda S, Ulrich HD, Dikic I, Friedberg ec (2006) Ubiquitin-Binding Motifs in Rev1 Protein are Required for Its Role in the Tolerance of 脫氧核糖核酸 Damage
Wu, J., Tang, SS501, and Bezprozvanny, I. (2006) Evaluation of clinically-relevant glutamate pathway inhibitors in in vitro model of Huntington’s disease。
Tang, T.S., Slow, E., Lupu, V., Stavrovskaya, I.G., Sugimori, M., Llinas, R., Kristal, B.S., Hayden, M.R., Bezprozvanny, I. (2005) Disturbed ca(clo)2+ signaling and apoptosis of medium spiny neurons in Huntington's disease。
[This work has been reported or reprinted by Medical News Today, EurekAlert, Innovations Report, BETTERHUMANS, News-Medical in Medical Research News, Datamonitor NewsWire]。
Ying Chen, Uwe Beffert, Mert Ertunc, Tie-Shan Tang, Ege T. Kavalali, Ilya Bezprozvanny , Joachim Herz (2005) Reelin modulates NMDA 捕手 activity in cortical neurons。
Tang, SS501, Bezprozvanny, I. (2004) Dopamine receptor-mediated ca(clo)2+ signaling in striatal medium spiny neurons。
Tu*, H., Tang*, T.S., Wang, Z., Bezprozvanny, I. (2004) Association of type 1 肌醇 1,4,5-trisphosphate 捕手 with AKAP9 (Yotiao) and protein kinase A
Tang, T.S., Tu, H., Orban, P.C., Chan, E.Y., Hayden, M.R., Bezprozvanny, I. (2004) HAP1 facilitates effects of mutant huntingtin on 肌醇-(1,4,5) tris磷酸鹽induced ca(clo)2+ release in striatal medium spiny neurons
Tang, T.S., Tu, H., Chan, E.Y., Maximov, A., Wang, Z., 惠靈頓, C.L., Hayden, M.R., Bezprozvanny, I. (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by 肌醇(1,4,5) trisphosphate 捕手 type 1。
a) Anurag Varshney and barbara E. Ehrlich (2003) Intracellular ca(clo)2+ Signaling and Human Disease: The Hunt Begins with Huntington's。
b) Colin Taylor, University of Cambridge, UK (2003) The Scientist。
c) Faculty of 1000 Biology: evaluations for Tang TS et al。
Tang*, T.S., Tu*, H., Wang, Z., and Bezprozvanny, I. (2003) Modulation of the type 1 inositol (1,4,5)-trisphosphate receptor 函數 by PKA and PP1-alpha。
Maximov*, A, Tang*,T.S., Bezprozvanny, I. (2003) Association of the 肌醇 (1,4,5)-trisphosphate receptors with 4.1N protein in neurons。
Tang, T.S., Dong, J.B., Huang, X.Y. and Sun, F.Z. (2000) ca(clo)2+ oscillations induced by a cytosolic sperm protein factor are mediated by a maternal machinery which functions only once in mammalian eggs。
Dong, J.B., Tang, T.S. and Sun, F.Z. (2000) Xenopus and chicken sperm contain a cytosolic soluble factor which can trigger calcium oscillations in mouse eggs。
Dong, Y., Tang, SS501, Lu, C.L., He, C., Dong, J.B., Huang, X.Y., Sun, F.Z., Bao, X. (2000) Pituitary adenylate cyclase activating polypeptide ameliorates the damage and inhibits the increase of intracellular calcium concentration in cultured hippocampal neurons induced by glutamate。
Guo, C.X., Tang, SS501, and Liu, Y.X. (2000) Germ cell apoptosis and regulation in testis。
Guo, C.X., Tang, T.S., Mu, X.M., Li, S.H., Fu, G.Q., Liu, H. and Liu, Y.X. (1999) Cloning of novel 溫度related expressed sequence tags in rat testis during spermatogenesis
Deng, M.Q., Huang, X.Y., Tang, T.S. and Sun, F.Z. (1998) Spontaneous and fertiliz。ation-induced ca(clo)2+ oscillations in mouse immature germinal vesicle-stage oocytes。
Tang, T.S. and Dou, Z.Y. (1993) Progress in establishment of embryonic stem (ES) cell lines from mammals. Acta Univ. Agric。
在國際上首先發現了神經細胞胞內鈣信號紊亂與亨廷頓氏神經退行性疾病（舞蹈病）的關系；并使用基因治療的方法，穩定了舞蹈病模型小鼠神經細胞的鈣信號，顯著延緩了疾病模型小鼠紋狀體神經細胞的退行性病變。近年來所取得的研究成果發表在國際核心學術期刊，包括Neuron、PNAS、J 神經科學、 Development、J Biol Chem等。迄今共發表SCI收錄論文25余篇，獲得美國專利一項。今后的研究重點將以小鼠、果蠅和斑馬魚等模式動物作為研究體系，利用分子細胞生物學、遺傳學和生物化學等技術，探討神經鈣信號紊亂，脫氧核糖核酸的損傷修復與神經退行性疾病的關系；探索以神經鈣信號傳導通路，DNA的損傷與修復通路為切入點的神經退行性疾病治療方案。目前作為項目負責人承擔了中科院百人計劃項目、中科院知識創新工程重要方向項目以及國家自然科學基金面上項目。
參考資料 >
唐鐵山.中國科學院動物研究所.2016-10-04